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Oral Epithelial Dysplasia: Can Quantifiable Morphological Features Help in the Grading Dilemma?

Administrative Information

Organisation

Oral Pathology Unit, School of Dentistry, The University of Birmingham.

Presentation Information

Full / Half Time Slot: Half Time Slot (25 min)

Contact / Speaker Name

Dr Rasha Abu Eid

Presentation Title

Oral Epithelial Dysplasia: Can Quantifiable Morphological Features Help in the Grading Dilemma?

Participant Requirements:

Intermediate Knowledge of the principles of image analysis and the use of ImageJ is required.

Biography of Speaker

Dr Rasha Fadel Abu Eid.
Born in Amman, Jordan on January the 6th 1978.
Received school education at Sisters of Nazareth School in Amman from 1983 till 1996. Graduated with distinction.
Enrolled in the Faculty of Dentistry at the University of Jordan and graduated in July 2001, ranking “very good”.
Obtained a PhD degree in Oral Pathology in January 2005 from the School of Dentistry, The University of Birmingham in England.
Currently works as a research fellow at the Oral Pathology Unit in the School of Dentistry, The University of Birmingham in England.
Research interests include the application of mathematics and image analysis in histopathological diagnosis, diagnosis of oral premalignant and malignant lesions and the aging of the oral mucosa.

Abstract

The epithelial lining of the oral cavity can sometimes experience certain changes that put it at a higher risk of undergoing malignant transformation. Such changes present clinically as 'premalignant' lesions that at the histological level feature pathological alterations known as epithelial dysplasia. However, the degree of alteration of tissues is routinely assessed visually, thus introducing an element of subjectivity to the diagnostic process. The aim of this work was to apply objective and quantitative image analysis techniques to one problematic area in histopathological diagnosis: the grading of the severity of epithelial dysplasia. Histopathological diagnosis (which depends to some degree on individual judgement of histological features by an observer) has been shown to be subject to intraand interobserver variations that affect the accuracy and reproducibility of the diagnostic process. Therefore, more quantitative methods, which do not depend on human perceptual skills, are preferable. In this paper we present a number of innovative techniques to assess a number of morphological features of different grades of oral epithelial dysplasia.

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